Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.

S Ogawa, D W Tank, R Menon, J M Ellermann, S G Kim, H Merkle, K Ugurbil

DSEID: DSEID-005-6343162
DOI: 10.1073/pnas.89.13.5951
Journal: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1992-7
Status: temporarily_unreachable

Abstract

We report that visual stimulation produces an easily detectable (5-20%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo images at 4-T magnetic-field strength. The observed changes predominantly occur in areas containing gray matter and can be used to produce high-spatial-resolution functional brain maps in humans. Reducing the image-acquisition echo time from 40 msec to 8 msec reduces the amplitude of the fractional signal change, suggesting that it is produced by a change in apparent transverse relaxation time T*2. The amplitude, sign, and echo-time dependence of these intrinsic signal changes are consistent with the idea that neural activation increases regional cerebral blood flow and concomitantly increases venous-blood oxygenation.

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Title: Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.
Delta ID: DSEID-005-6343162
Authors: S Ogawa, D W Tank, R Menon, J M Ellermann, S G Kim, H Merkle, K Ugurbil
Abstract source: crossref
Source URL: https://doi.org/10.1073/pnas.89.13.5951
Access: closed_or_uncertain
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